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178312-62-4 - Homomorpholine hydrochloride, 98% - Hexahydro-1,4-oxazepine hydrochloride - 1,4-Oxazepane hydrochloride - B21749 - Alfa Aesar

B21749 Homomorpholine hydrochloride, 98%

Codice CAS
178312-62-4
Sinonimi
Hexahydro-1,4-oxazepine hydrochloride
1,4-Oxazepane hydrochloride

Dimensioni Prezzo ($) Quantità Disponibilità
1g 251,32
5g 917,73
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Homomorpholine hydrochloride, 98%

MDL
MFCD02683070

Proprietà chimiche

Formula
C5H11NO•HCl
Peso formula
137.61
Punto di fusione
158-164°
Sensibilità
Hygroscopic
Solubilità
Slightly soluble in water.

Applicazioni

Homomorpholine Hydrochloride is a useful synthetic intermediate. It is used to prepare homomorpholine oxazolidinone with antibacterial activities. It is also used to synthesize A2A adenosine receptor antagonists for the treatment of Parkinson's disease.

Note

Hygroscopic. Keep away from oxidizing agents, water/moisture. Store under inert atmosphere. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

Letteratura

Ji-Young Kim; Frederick E. Boyer; Allison L. Choy; Michael D. Huband; Paul J. Pagano; J.V.N. Vara Prasad. Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agents.Bioorganic & Medicinal Chemistry Letters.200919(2), 550-553.

Zhang, X., et al. Lead Optimization of 4-Acetylamino-2-(3,5-dimethylpyrazol-1-yl)-6-pyridylpyrimidines as A2A Adenosine Receptor Antagonists for the Treatment of Parkinson’s Disease.J. Med. Chem.200851(22), 7099-7110.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2934.99
TSCA
No

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