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128796-39-4 - 4-(Trifluoromethyl)benzeneboronic acid, 98% - 4-(Trifluoromethyl)phenylboronic acid - B22374 - Alfa Aesar

B22374 4-(Trifluoromethyl)benzeneboronic acid, 98%

Codice CAS
128796-39-4
Sinonimi
4-(Trifluoromethyl)phenylboronic acid

Dimensioni Prezzo ($) Quantità Disponibilità
1g 60,30
5g 193,00
25g 796,00
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4-(Trifluoromethyl)benzeneboronic acid, 98%

MDL
MFCD00151855
EINECS
000-000-0

Proprietà chimiche

Formula
C7H6BF3O2
Peso formula
189.93
Punto di fusione
238-242°
Solubilità
Soluble in DMSO, not in water

Applicazioni

4-(Trifluoromethyl)benzeneboronic acid is used of this drug is to N-arylate imidazoles and amines with copper-exchanged fluorapatite, as well as used in microwave-promoted cross-coupling with acid chlorides leading to aryl ketones.

Note

Keep container tightly closed. Store in cool, dry conditions in well sealed containers.

Letteratura

Cao KS.; Bian HX.; Zheng WH. Mild arylboronic acid catalyzed selective [4 + 3] cycloadditions: access to cyclohepta[b]benzofurans and cyclohepta[b]indoles. Org Biomol Chem. 2015, 13, (23), 6449-52.

Maki T.; Ishihara K.; Yamamoto H. 4,5,6,7-Tetrachlorobenzo[d][1,3,2]dioxaborol- 2-ol as an effective catalyst for the amide condensation of sterically demanding carboxylic acids. Org Lett.2006, 8, (7), 1431-4.

For phosphine-free palladium-catalyzed Suzuki coupling with aryl halides, see: J. Org. Chem., 59, 5034 (1994).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
3544189
Codice tariffe armonizzato
2931.90
TSCA
No

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