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65-49-6 - 4-Aminosalicylic acid, 98+% - 4-Amino-2-hydroxybenzoic acid - B23289 - Alfa Aesar

B23289 4-Aminosalicylic acid, 98+%

Codice CAS
65-49-6
Sinonimi
4-Amino-2-hydroxybenzoic acid

Dimensioni Prezzo ($) Quantità Disponibilità
100g 25,00
500g 81,80
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4-Aminosalicylic acid, 98+%

MDL
MFCD00007789
EINECS
200-613-5

Proprietà chimiche

Formula
C7H7NO3
Peso formula
153.14
Punto di fusione
ca 135-145° dec.
Solubilità
Soluble in water (2 g/L) at 20°C, dilute sodium hydroxide, dilute nitric acid, ether (slightly), methanol, acetone, and ethanol. Virtually insoluble in benzene, chloroform, and carbon tetrachloride.

Applicazioni

Competitive pteridine synthetase inhibitor, has antibacterial capable of inhibiting the growth of Mycobacterium tuberculosis. It inhibits NF-κB and folic acid synthesis.

Note

Store in cool, dry place in a well sealed container. Store away from oxidizing agents.

Letteratura

Pawel Grobelny; Arijit Mukherjeea and Gautam R. Desiraju. Drug-drug co-crystals: Temperature-dependent proton mobility in the molecular complex of isoniazid with 4-aminosalicylic acid. CrystEngComm. 2011, 13 (13), 4358-4364.

John Gandolfo; Louis A. Weiss; Michael Farthing, George Powers; Kathleen Eagen; Michael Goldberg; Phillip Berman; Marshall Kaplan. 4-Aminosalicylic acid retention enemas in treatment of distal colitis. Digestive Diseases and Sciences. 1987, 32 (7), 700-704.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,477
Beilstein
473071
Codice tariffe armonizzato
2922.50
TSCA
Yes
RTECS
VO1225000

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