Informativa e consenso per l'uso dei cookie

Accetto Il nostro sito salva piccoli pezzi di informazioni (cookie) sul dispositivo, al fine di fornire contenuti migliori e per scopi statistici. È possibile disattivare l'utilizzo di cookies modificando le impostazioni del tuo browser. Continuando la navigazione si acconsente all'utilizzo dei cookie.

496-76-4 - 2,4,5-Trihydroxypyrimidine, 98% - Isobarbituric acid - B23320 - Alfa Aesar

B23320 2,4,5-Trihydroxypyrimidine, 98%

Codice CAS
496-76-4
Sinonimi
Isobarbituric acid

2,4,5-Trihydroxypyrimidine, 98%

MDL
MFCD00082987
EINECS
207-829-9

Proprietà chimiche

Formula
C4H4N2O3
Peso formula
128.09
Punto di fusione
>300°
Solubilità
Soluble in DMSO (Sparingly), Methanol (Sparingly).

Applicazioni

2,4,5-Trihydroxypyrimidine studies show that it can form stable base pairs with all four bases in a DNA duplex. It has been used as oxidative DNA damage biomarker in tissue engineered skin. It acts as an antagonist of uracil in the growth of Lactobacillus casei.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible materials are oxidizing agents.

Letteratura

William R Markesbery; Mark A Lovell. DNA oxidation in Alzheimer's disease. Antioxidants and Redox Signaling.2006, 8, (11-12), 2039-2045.

Maria D Aamann; Martin M Sorensen; Christina Hvitby; Brian R Berquist; Meltem Muftuoglu; Jingyan Tian; Nadja C de Souza-Pinto; Morten Scheibye-Knudsen; David M Wilson; Tinna Stevnsner; Vilhelm A Bohr. Cockayne syndrome group B protein promotes mitochondrial DNA stability by supporting the DNA repair association with the mitochondrial membrane. FASEB Journal.2010, 24, (7), 2334-2346.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
127205
Codice tariffe armonizzato
2933.59
TSCA
No

Raccomandato

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio