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103-74-2 - 2-(2-Hydroxyethyl)pyridine, 99% - 2-Pyridineethanol - 2-(2-Pyridyl)ethanol - B23579 - Alfa Aesar

B23579 2-(2-Hydroxyethyl)pyridine, 99%

Codice CAS
103-74-2
Sinonimi
2-Pyridineethanol
2-(2-Pyridyl)ethanol

Dimensioni Prezzo ($) Quantità Disponibilità
100g 27,20
500g 85,20
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2-(2-Hydroxyethyl)pyridine, 99%

MDL
MFCD00006364
EINECS
203-140-2

Proprietà chimiche

Formula
C7H9NO
Peso formula
123.16
Punto di fusione
-8°
Punto di ebollizione
235-238°
Punto di infiammabilità
117°(243°F)
Densità
1.095
Indice di rifrazione
1.5370
Sensibilità
Hygroscopic
Solubilità
Soluble in Chloroform (Slightly), Methanol (Slightly).

Applicazioni

2-(2-Hydroxyethyl)pyridine is a metabolite of the anti-vertigo drug Betahistine. It acts as a reagent for protection of the 5'-phosphate of nucleotides as 2-pyridylethyl (Pet) esters. It is used for carboxyl protection of amino acids. It is also used to cleave such groups as Boc and Fmoc, and also to hydrogenolysis. It was used to prepare mononuclear nickel(II) acetate.

Note

Hygroscopic. Store under dry inert gas. Store away from moisture, strong bases and oxidizing agents. Protect from humidity and water.

Letteratura

Miha Trdin; Valter Bergant; Ivan Leban; Nina Lah. Two concomitant polymorphs of monomeric nickel acetate with 2-pyridineethanol. Acta Chimica Slovenica. 2012, 59, (3), 478-483.

Takashi Niwa; Hideki Yorimitsu; Koichiro Oshima. Palladium-Catalyzed 2-Pyridylmethyl Transfer from 2-(2-Pyridyl)ethanol Derivatives to Organic Halides by Chelation-Assisted Cleavage of Unstrained Cmath image[BOND]Cmath image Bonds. Angewandte Chemie (International Edition). 2007, 46, (15), 2643-2645.

Reagent for protection of the 5'-phosphate of nucleotides as 2-pyridylethyl (Pet) esters. The group can be introduced by DCC-coupling, is stable to mild base, but can be cleaved by methoxide in pyridine-methanol: Chem. Ber., 103, 1032 (1970).

Has also been used for carboxyl protection of amino acids. Pet esters are stable to both mildly acidic and basic conditions used to cleave such groups as Boc and Fmoc, and also to hydrogenolysis. Cleavage is by quaternization with methyl iodide in the presence of mild base: Tetrahedron Lett., 25, 3971 (1984); Angew. Chem. Int. Ed., 23, 716 (1984). See Appendix 6.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H227-H315-H319-H335

Combustible liquid. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P210u-P261-P280a-P305+P351+P338-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
111205
Codice tariffe armonizzato
2933.39
TSCA
Yes
RTECS
UT2970450

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