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7669-54-7 - 2-Nitrobenzenesulfenyl chloride, 97% - 2-Nitrophenylsulfenyl chloride - B23627 - Alfa Aesar

B23627 2-Nitrobenzenesulfenyl chloride, 97%

Codice CAS
7669-54-7
Sinonimi
2-Nitrophenylsulfenyl chloride

Dimensioni Prezzo ($) Quantità Disponibilità
10g 50,40
50g 169,00
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2-Nitrobenzenesulfenyl chloride, 97%

MDL
MFCD00007128
EINECS
231-644-2

Proprietà chimiche

Formula
C6H4ClNO2S
Peso formula
189.62
Punto di fusione
72-75°
Sensibilità
Moisture Sensitive
Solubilità
Reacts with water.

Applicazioni

2-Nitrobenzenesulfenyl chloride is used as a reagent for N-protection as N-2-nitrophenylsulfenyl (Nps) derivatives, in amino acids and peptides and nucleosides.

Note

Store under dry inert gas. Store away from moisture, strong bases and oxidizing agents. Protect from humidity and water.

Letteratura

Norman Kharasch; Herbert L. Wehrmeister; Henry Tigerman. Derivatives of Sulfenic Acids. I. Reactions of 2-Nitrobenzenesulfenyl Chloride, 2,4-Dinitrobenzenesulfenyl Chloride and of the Corresponding Sulfenyl Thiocyanates with Olefins and with Methyl Ketones. J. Am. Chem. Soc. 1947, 69, (7), 1612-1615.

Reagent for N-protection as N-2-nitrophenylsulfenyl (Nps) derivatives, in amino acids and peptides: J. Am. Chem. Soc., 85, 3660 (1963); 87, 99 (1965); Biochemistry, 7, 971, 980 (1968); Synthesis, 512 (1985); Helv. Chim. Acta, 66, 602 (1983), and nucleosides: J. Org. Chem., 54, 2321 (1989). The Nps group is readily cleaved by dilute acid. For cleavage with thioacetamide, see: Helv. Chim. Acta, 49, 1330 (1966).

The chemistry of sulfenyl halides has been reviewed: Synthesis, 563, 617 (1971).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
473741
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2930.90
TSCA
Yes

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