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67-20-9 - Nitrofurantoin, 98% - N-(5-Nitro-2-furfurylidene)-1-aminohydantoin - B24079 - Alfa Aesar

B24079 Nitrofurantoin, 98%

Codice CAS
67-20-9
Sinonimi
N-(5-Nitro-2-furfurylidene)-1-aminohydantoin

Dimensioni Prezzo ($) Quantità Disponibilità
25g 42,54
100g 98,40
500g 392,80
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Nitrofurantoin, 98%

MDL
MFCD00003224
EINECS
200-646-5

Proprietà chimiche

Formula
C8H6N4O5
Peso formula
238.16
Punto di fusione
ca 265° dec.
Sensibilità
Light Sensitive & Hygroscopic
Solubilità
Soluble in water (<0.01 g/100 ml at 19°C), dimethyl sulfoxide and methanol.

Applicazioni

Nitrofurantoin is a nitrofuran antibiotic that is used as a substrate of bacterial nitrofuran reductase to study the interactions of active metabolites with DNA, ribosomal proteins and metabolic and pro-oxidant processes. It is an antibactericidal compound that has been historically prepared by the reaction of 1-aminohydantoin sulfate and 5-nitro-2-furaldehyde diacetate. It shows activity against many Gram-positive and Gram-negative bacteria. Nitrofurantoin is effective against enterococci, staphylococci, streptococci, corneybacteria, many strains of Escherichia coli.

Note

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Store under dry inert gas. It is hygroscopic in nature. Incompatible with oxidizing agents. It is sensitive to light.

Letteratura

Charles C. McOsker.; Penny M. Fitzpatrick. Nitrofurantoin: Mechanism of action and implications for resistance development in common uropathogens. J. Antimicrob. Chemother. 1994, 33 23-30.

P. R. Hari.; T. Chandy.; C. P. Sharma. Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. Journal of Microencapsulation: Micro and Nano Carriers. 1996, 13 (3), 319-329.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H334-H317-H302

May cause allergy or asthma symptoms or breathing difficulties if inhaled. May cause an allergic skin reaction. Harmful if swallowed.

Dichiarazioni precauzionali: P285-P261-P280-P342+P311-P301+P312-P363-P304+P341-P321-P333+P313-P501a

In case of inadequate ventilation wear respiratory protection. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. IF INHALED: If breathing is difficult, remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment (see label). If skin irritation or rash occurs: Get medical advice/attention. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2934.99
TSCA
Yes
RTECS
MU2800000

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