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116-54-1 - Methyl dichloroacetate, 99% - Dichloroacetic acid methyl ester - B24399 - Alfa Aesar

B24399 Methyl dichloroacetate, 99%

Codice CAS
116-54-1
Sinonimi
Dichloroacetic acid methyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
100g 26,82
500g 59,12
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Methyl dichloroacetate, 99%

MDL
MFCD00000843
EINECS
204-146-8

Proprietà chimiche

Formula
C3H4Cl2O2
Peso formula
142.97
Punto di fusione
-52°
Punto di ebollizione
142-144°
Punto di infiammabilità
70°(158°F)
Densità
1.380
Indice di rifrazione
1.4420
Solubilità
Soluble in water. (4 g/L).

Applicazioni

Methyl dichloroacetate may be used in the diastereoselctive synthesis of bicyclic chlorocyclopropane, as difunctional initiator during atom transfer radical polymerization of methyl or n-butyl acrylate, as reagent during CrCl2-induced olefination of aldehydes. It is a reactant involved in nucleophilic substitution reactions with nitro(pentafluorosulfanyl)benzenes, azide-alkyl halide cycloaddition and atom transfer radical addition, Chemical modification of STn antigen for enhancement of synthetic carbohydrate vaccines, three component reaction of arynes with cyclic ethers and active methines, catalytic radical haloalkylation for synthesis of neodysidenin and addition reactions for syntehsis of enantiopure 3,4-diamino esters or amides.

Note

Store at room temperature. Incompatible with oxidizing agents. Ensure proper ventilation.

Letteratura

Ana Escribano.; Concepción Pedregal.; Rosario González.; Alejandro Fernández.; Keith Burton.; Gregory A Stephenson. Diastereoselective cyclopropanation of cyclic enones with methyl dichloroacetate anion. Tetrahedron. 2001, 57 (46),9423-9427 .

Yoshiyuki Mido.; Masao Hashimoto. Conformational isomerism of methyl dichloroacetate. An infrared, Raman and 35Cl NQR study. J. Mol. Struct. 1985, 131 (1-2), 71-81 .

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H332-H315-H319-H335-H227

Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Dichiarazioni precauzionali: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2915.40
TSCA
Yes
RTECS
AG6625000

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