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63503-60-6 - 3-Chlorobenzeneboronic acid, 97% - 3-Chlorophenylboronic acid - B24444 - Alfa Aesar

B24444 3-Chlorobenzeneboronic acid, 97%

Codice CAS
63503-60-6
Sinonimi
3-Chlorophenylboronic acid

Dimensioni Prezzo ($) Quantità Disponibilità
1g 18,40
5g 53,50
25g 210,00
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3-Chlorobenzeneboronic acid, 97%

MDL
MFCD00161354
EINECS
000-000-0

Proprietà chimiche

Formula
C6H6BClO2
Peso formula
156.38
Punto di fusione
180-185°
Solubilità
Slightly soluble in water. soluble in ether, tetrahydrofuran,, dimethyl sulfoxide, dimethyl formamide, methanol.

Applicazioni

It is employed as a reactant involved in 1,4-conjugate addition reactions with ethenesulfonamides to form arylethanesulfonamides, Suzuki-Miyaura reactions with dibromotrifluoromethylbenzene, cross-coupling reactions with diazoesters3 or potassium cyanate. It is involved in the synthesis of biarylketones and phthalides and synthesis of inhibitors including PDE4 inhibitors6 among others.

Note

Store at room temperature. Incompatible with oxidizing agents.

Letteratura

Robert E. London.; Scott A. Gabel. Fluorine-19 NMR Studies of Fluorobenzeneboronic Acids. 2. Kinetic Characterization of the Interaction with Subtilisin Carlsberg and Model Ligands.J. Am. Chem. Soc. 1994, 116 (6),2570-2575 .

Edward J. Farrington.; Christopher F. J. Barnard.; Elizabeth Rowsell. ;John M. Brown. Ruthenium Complex-Catalysed Heck Reactions of Areneboronic Acids; Mechanism, Synthesis and Halide Tolerance.Advanced Synthesis & Catalysis. 2005, 347 (1),185-195 .

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
2936343
Codice tariffe armonizzato
2931.90
TSCA
No

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