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Isobutyryl chloride is used in the preparation of fully isobutyramide terminated hyperbranched polyethylenimines. It plays an important role in the separation and identification of shikonin and its ester derivatives in the root epidermis of Echium italicum L. It acts as an acylating agent for the ketimine derivatives of alfa-amino esters, nucleosides and pyrroles. Further, it is used in the preparation of organic peroxides. In addition to this, it is used as an intermediate for dyes, textile auxiliaries and peroxide compounds.
Sparling, B. A.; Tucker, J. K.; Moebius, D. C.; Shair, M. D. Total Synthesis of (-)-Nemorosone and (+)-Secohyperforin. Org. Lett. 2015, 17 (14), 3398-3401.
Lopchuk, J. M.; Gribble, G. W. Total synthesis of atorvastatin via a late-stage, regioselective 1,3-dipolar münchnone cycloaddition. Tetrahedron Lett. 2015, 56 (23), 3208-3211.
Dichiarazioni di rischio (UE): H225-H314
Highly flammable liquid and vapour. Causes severe skin burns and eye damage.
Dichiarazioni precauzionali: P210-P260u-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dusts or mists. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.