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Pyruvic aldehyde is used in the synthesis and cytotoxicity evaluation of N-terminal analogues of tubulysin-U an antimitotic compound. Also used in the synthesis of imidazoles as potent calcitonin gene-related CGRP antagonists.
Paul J Beisswenger; Keith S Drummond; Robert G Nelson; Scott K Howell; Benjamin S Szwergold; Michael Mauer. Susceptibility to diabetic nephropathy is related to dicarbonyl and oxidative stress. Diabetes. 2005, 54 (11), 3274-3281.
Katrien H J Gaens; Coen D A Stehouwer; Casper G Schalkwijk. Advanced glycation endproducts and its receptor for advanced glycation endproducts in obesity. Current Opinion in Lipidology. 2013, 24 (1), 4-11.
Dichiarazioni di rischio (UE): H290-H302-H318-H317-H341
May be corrosive to metals. Harmful if swallowed. Causes serious eye damage. May cause an allergic skin reaction. Suspected of causing genetic defects.
Dichiarazioni precauzionali: P201-P261-P280-P305+P351+P338-P405-P501a
Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.