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66648-50-8 - Ethyl 3,4-dihydroxycinnamate, 97% - Ethyl caffeate - 3,4-Dihydroxycinnamic acid ethyl ester - B24808 - Alfa Aesar

B24808 Ethyl 3,4-dihydroxycinnamate, 97%

Codice CAS
66648-50-8
Sinonimi
Ethyl caffeate
3,4-Dihydroxycinnamic acid ethyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
1g 39,40
5g 129,00
25g 481,00
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Ethyl 3,4-dihydroxycinnamate, 97%

MDL
MFCD00045754

Proprietà chimiche

Formula
C11H12O4
Peso formula
208.22

Applicazioni

Ethyl 3,4-dihydroxycinnamate shows anti-inflammatory, immunomodulatory, and anti-carcinogenic properties. It is a potent and specific inhibitor of NF-κB and its downstream inflammatory mediators: NOS2 (inducible nitric oxide synthase; NOS; NOS II), Cox-2 (cyclooxygenase-2), and prostaglandin E2 (PGE2). Ethyl 3,4-Dihydroxycinnamate prevents DNA single-strand breaks caused by H2O2.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Incompatible materials are oxidizing agents Store at -20°C.

Letteratura

Yi-Ming Chiang; Chiu-Ping Lo; Yi-Ping Chen; Sheng-Yang Wang; Ning-Sun Yang; Yueh-Hsiung Kuo and Lie-Fen Shyur. Ethyl caffeate suppresses NF-κB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2in vitro or in mouse skin. British Journal of Pharmacology. 2003, 146, 352-363.

Meixian Xiang; Hanwen Su; Jinyue Hu and Yunjun Yan. Isolation, identification and determination of methyl caffeate, ethyl caffeate and other phenolic compounds from Polygonum amplexicaule var. sinense. Journal of Medicinal Plants Research. 2003, 5, (9), 1685-1691.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2918.29
TSCA
No

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