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1892-57-5 - 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98% - N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide - B25057 - Alfa Aesar

B25057 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98%

Codice CAS
1892-57-5
Sinonimi
N-Ethyl-N'-(3-dimethylaminopropyl)carbodiimide

Dimensioni Prezzo ($) Quantità Disponibilità
5g 79,60
25g 274,00
100g 1006,00
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1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide, 98%

MDL
MFCD00044916
EINECS
217-579-2

Proprietà chimiche

Formula
C8H17N3
Peso formula
155.24
Punto di ebollizione
66-68°/1mm
Punto di infiammabilità
>110°(230°F)
Densità
0.885
Indice di rifrazione
1.4610
Sensibilità
Air & Moisture Sensitive
Solubilità
Soluble in water.

Applicazioni

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide is used as a carboxyl activating agent and activate phosphate groups in phospho mono and di esters. It is used in peptide synthesis, 3'-amino-3'-deoxyadenosine-5'-di- and triphosphates and in the preparation of antibodies like immunoconjugates. It plays a vital role for immobilization of large biomolecules in association with N-hydroxysuccinimide. It is also used in the acylation of phosphoranes.

Note

Air sensitive. Incompatible with strong acids and strong oxidizing agents.

Letteratura

Free base form of 'Water-soluble' carbodiimide. For applications see following entry. In the presence of CuCl2, (E)- or (Z)-2-substituted 3-hydroxy-3-phenylpropionate esters can be dehydrated stereoselectively to the corresponding (E) or (Z)-cinnamates: Tetrahedron Lett., 40, 5019 (1999).

Li, J.; Yue, L.; Li, C.; Pan, Y.; Yang, L. Enantioselectivity and catalysis improvements of Pseudomonas cepacia lipase with Tyr and Asp modification. Catal. Sci. Technol. 2015, 5, 2681-2687.

Lopez, R. J.; Babanova, S.; Artyushkova, K.; Atanassov, P. Surface modifications for enhanced enzyme immobilization and improved electron transfer of PQQ-dependent glucose dehydrogenase anodes. Bioelectrochemistry 2015, 105, 78-87.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260u-P303+P361+P353-P305+P351+P338-P301+P330+P331-P405-P501a

IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
507429
Classe di rischio
8
Gruppo di imballaggio
III
Codice tariffe armonizzato
2925.19
TSCA
Yes

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