B25187 6(5H)-Phenanthridinone, 96%
SDS
| Dimensioni | Prezzo ($) | Quantità | Disponibilità |
|---|---|---|---|
| 1g | 38,60 |
|
|
| 5g | 140,00 |
|
|
6(5H)-Phenanthridinone, 96%
Proprietà chimiche
Applicazioni
6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.
Note
Letteratura
Guoyong Song; Dan Chen; Cheng-Ling Pan; Robert H Crabtree; Xingwei Li. Rh-catalyzed oxidative coupling between primary and secondary benzamides and alkynes: synthesis of polycyclic amides. Journal of Organic Chemistry.2010, 75, (21), 7487-7490.
D Weltin; J Marchal; P Dufour; E Potworowski; D Oth; P Bischoff. Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. Oncology Research.1994, 6, (9), 399-403.
Rischio GHS e dichiarazioni precauzionali
Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a
Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.
