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1015-89-0 - 6(5H)-Phenanthridinone, 96% - B25187 - Alfa Aesar

B25187 6(5H)-Phenanthridinone, 96%

Codice CAS
1015-89-0
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 38,60
5g 140,00
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6(5H)-Phenanthridinone, 96%

MDL
MFCD00004988
EINECS
213-804-3

Proprietà chimiche

Formula
C13H9NO
Peso formula
195.22
Punto di fusione
288-294°
Solubilità
Soluble in DMSO (5 mg/ml). Insoluble in water.

Applicazioni

6(5H)-Phenanthridinone is used as a probe into the role of PARP in cellular response to irradiation. Treatment of cells with 6(5H)-Phenanthridinone and various DNA-damaging agents showed a resistance to apoptosis. It acts as a reactant in the synthesis of 5,6-dihydrophenanthridine sulfonamides, oxidative coupling with diphenylacetylene, direct copper acetate-catalyzed N-cyclopropylation of cyclic amides. It is used as HIV-1 integrase inhibitor.

Note

Incompatible materials are oxidizing agents. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

Letteratura

Guoyong Song; Dan Chen; Cheng-Ling Pan; Robert H Crabtree; Xingwei Li. Rh-catalyzed oxidative coupling between primary and secondary benzamides and alkynes: synthesis of polycyclic amides. Journal of Organic Chemistry.2010, 75, (21), 7487-7490.

D Weltin; J Marchal; P Dufour; E Potworowski; D Oth; P Bischoff. Effect of 6(5H)-phenanthridinone, an inhibitor of poly(ADP-ribose) polymerase, on cultured tumor cells. Oncology Research.1994, 6, (9), 399-403.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
140641
Codice tariffe armonizzato
2933.79
TSCA
No
RTECS
SG0370000

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