Informativa e consenso per l'uso dei cookie

Accetto Il nostro sito salva piccoli pezzi di informazioni (cookie) sul dispositivo, al fine di fornire contenuti migliori e per scopi statistici. È possibile disattivare l'utilizzo di cookies modificando le impostazioni del tuo browser. Continuando la navigazione si acconsente all'utilizzo dei cookie.

65-86-1 - Orotic acid, anhydrous, 97% - 1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid - Uracil-4-carboxylic acid - B25349 - Alfa Aesar

B25349 Orotic acid, anhydrous, 97%

Codice CAS
65-86-1
Sinonimi
1,2,3,6-Tetrahydro-2,6-dioxopyrimidine-4-carboxylic acid
Uracil-4-carboxylic acid

Dimensioni Prezzo ($) Quantità Disponibilità
100g 84,40
500g 230,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

Orotic acid, anhydrous, 97%

MDL
MFCD00006027
EINECS
200-619-8

Proprietà chimiche

Formula
C5H4N2O4
Peso formula
156.10
Punto di fusione
344-347°
Solubilità
Slightly soluble in water.

Applicazioni

Orotic acid is an intermediate in de novo pyrimidine biosynthesis that may be used to study the specificity and kinetics of orotate phosphoribosyltransferase (OPRT) which catalyzes the reversible phosphoribosyl transfer from 5?-phospho-α-d-ribose 1?-diphosphate (PRPP) to orotic acid (OA), forming pyrophosphate and orotidine 5?-monophosphate (OMP). It is used as a starting material for the potential commercial bioproduction of uridine 5?-monophosphate (UMP) by microbes such as Corynebacterium ammoniagenes (ATCC 6872) or Saccharomyces cerevisiae. It may be used to study the AMPK/SREBP-1 dependent cell signaling pathway and transcription regulation mechanisms that induce hepatic lipogenesis.

Note

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Letteratura

Eun-Jeong Jung; Sung-Won Kwon; Byung-Hwa Jung; Seon-Hee Oh; Byung-Hoon Lee. Role of the AMPK/SREBP-1 pathway in the development of orotic acid-induced fatty liver. Journal of Lipid Research. 2011, 52,(9), 1617-1625.

 

Xing Wang; Xiuwen Wang; Mengxin Yin; Zijun Xiao; Cuiqing Ma; Zhixin Lin; Peng George Wang; Ping Xu. Production of uridine 5'-monophosphate by Corynebacterium ammoniagenes ATCC 6872 using a statistically improved biocatalytic process. Applied Microbiology and Biotechnology. 2007, 76,(2), 321-328.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H315-H319

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P280-P264-P270-P305+P351+P338-P362-P301+P312-P321-P332+P313-P337+P313-P501a

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2933.59
TSCA
Yes
RTECS
RM3180000

Raccomandato

  • A15398

    Hydroxylamine hydrochloride, 99%
  • L03521

    Cyclobutyl methyl ketone, 97%
  • 47019

    Palladium, 5% on activated carbon powder, Type A109047-5, standard, reduced, nominally 50% water wet

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio