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An Acetanilide and Anisole derivative metabolite by liver. It is used to produce (5-fluoro-2-methoxy-phenyl)-(4-trifluoromethyl-phenyl)-methanone by reaction with 4-trifluoromethyl-benzonitrile. The reaction occurs with reagent Mg and solvent diethyl ether with other condition of heating for 2 hours. The yield is about 82%.
Karsten Menzel,; Fouzia Machrouhi,; Matthew Bodenstein,; Anthony Alorati,; Cameron Cowden,; Andrew W. Gibson,; Brian Bishop,; Norihiro Ikemoto,; Todd D. Nelson,; Michael H. Kress,; Doug E. Frantz. Process Development of a Potent Bradykinin 1 Antagonist. Org. Process Res. Dev2009, 13(3),519-524.
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.