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30827-99-7 - 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97% - AEBSF - H26473 - Alfa Aesar

H26473 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%

Codice CAS
30827-99-7
Sinonimi
AEBSF

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 198,00
1g 529,60
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4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride, 97%

MDL
MFCD00132962

Proprietà chimiche

Formula
C8H10FNO2S•HCl
Peso formula
239.69
Punto di fusione
ca 184° dec.
Sensibilità
Moisture Sensitive
Solubilità
Soluble in water 50 mg/mL or 100% ethanol.

Applicazioni

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

Note

Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, air, moisture.

Letteratura

Lawson, W.B., et al,; Folia Haematol. Int. Mag. Klin. Studies on the inhibition of human thrombin: effects of plasma and plasma constituents. Morphol. Blutforsch. 1982, 109(52)

M Citron,; T.S Diehl,; A Capell,; C Haass,; D.B Teplow,; D.J Selkoe. Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF. Journal name. 1996, 17 (1),171-179.

Irreverersible serine protease inhibitor: Thromb. Res., 2, 343 (1973); Acta Biol. Med. Ger., 39, 355 (1980).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
7604627
Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2922.29
TSCA
No

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