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18107-18-1 - (Trimethylsilyl)diazomethane, 2M in hexanes - (Diazomethyl)trimethylsilane - H26744 - Alfa Aesar

H26744 (Trimethylsilyl)diazomethane, 2M in hexanes

Codice CAS
18107-18-1
Sinonimi
(Diazomethyl)trimethylsilane

Dimensioni Prezzo ($) Quantità Disponibilità
5ml 58,30
25ml 190,00
100ml 606,00
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(Trimethylsilyl)diazomethane, 2M in hexanes

MDL
MFCD00053946

Proprietà chimiche

Formula
C4H10N2Si
Peso formula
114.22
Punto di infiammabilità
-23°(-10°F)
Densità
0.718
Sensibilità
Moisture & Light Sensitive
Solubilità
Immiscible with water. Miscible with organic solvents.

Applicazioni

(Trimethylsilyl)diazomethane is used as a methylating agent in organic chemistry. It is utilized in Gas Chromatography- Mass-Spectrometry (GC-MS) for the analysis of various carboxylic compounds. It is involved as a reagent in the Doyle-Kirmse reaction with allyl sulfides and allyl amines. It is considered and used as a less-explosive replacement fordiazomethane. It is also used as a reactant for Unnatural alfa-amino acid derivatives containing gem-bisphosphonates through Michael addition reaction, imidazolo[2,1-b]benzothiazole derivatives and aigialomycin D analogues.

Note

(Trimethylsilyl)diazomethane (TMSD) in alcoholic solvents under acidic or basic conditions can lead to the formation of diazomethane. TMSD is under review by the National Toxicological Program for potential inhalation hazards.Incompatible with oxidizing agents, chlorine, fluorine and perchlorates.

Letteratura

Kumar, R.; Turcaud, S.; Micouin, L. The Reaction of Dimethylalkynylaluminum Reagents with Trimethylsilyldiazomethane: Original Reactivity Leading to New alpha-Silylated Alkynyl Hydrazones. 2014, 16 (23), 6192-6195.

Kang, B. C.; Shim, S. Y.; Ryu, D. H. Highly Stereoselective Oxazaborolidinium Ion Catalyzed Synthesis of (Z)-Silyl Enol Ethers from Alkyl Aryl Ketones and Trimethylsilyldiazomethane. 2014, 16 (8), 2077-2079.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H331-H315-H336-H350-H304-H361-H373-H411

Highly flammable liquid and vapour. Toxic if inhaled. Causes skin irritation. May cause drowsiness or dizziness. May cause cancer. May be fatal if swallowed and enters airways. Suspected of damaging fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Toxic to aquatic life with long lasting effects.

Dichiarazioni precauzionali: P210-P260-P201-P261-P273-P280-P301+P310-P303+P361+P353-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
1902903
Classe di rischio
6.1
Gruppo di imballaggio
I
Codice tariffe armonizzato
2931.90
TSCA
No

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