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117924-33-1 - Di-tert-butyl N,N-diethylphosphoramidite, 94% - H27380 - Alfa Aesar

H27380 Di-tert-butyl N,N-diethylphosphoramidite, 94%

Codice CAS
117924-33-1
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 63,70
5g 196,00
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Di-tert-butyl N,N-diethylphosphoramidite, 94%

MDL
MFCD00134307

Proprietà chimiche

Formula
[(CH3)3CO]2PN(CH2CH3)2
Peso formula
249.33
Punto di ebollizione
39-41°/0.3mm
Punto di infiammabilità
78°(172°F)
Densità
0.896
Indice di rifrazione
1.434
Sensibilità
Moisture Sensitive
Solubilità
Hydrolyzes in water. Soluble in chloroform and methanol.

Applicazioni

A useful reagent for the efficient phosphorylative conversion of alcohols into their corresponding dibenzylphosphorotriesters. It is applied as a phosphitylating agent in water-soluble phosphate prodrugs of 1-propargyl-8-styrylxanthine derivatives, a2a-selective adenosine receptor antagonists.

Note

Moisture sensitive. Store away from water/moisture, heat and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store under inert gas. Keep it refrigerated. Keep ignition sources away.

Letteratura

Perich. J. W, et al. Di-tert-butyl N,N-diethylphosphoramidite. A new phosphitylating agent for the efficient phosphorylation of alcohols.Synthesis.,1988,2142-144.

Roland Sauer, et al. Water-Soluble Phosphate Prodrugs of 1-Propargyl-8-styrylxanthine Derivatives, A2A-Selective Adenosine Receptor Antagonists.J. Med. Chem.,2000,43(3), 440-448.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H227-H315-H319

Combustible liquid. Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P260u-P201-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310a-P405-P501a

Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2931.39
TSCA
No

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