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95010-17-6 - Vinylboronic anhydride pyridine complex, 95% - O'Shea's reagent - Trivinylboroxin pyridine complex - H28703 - Alfa Aesar

H28703 Vinylboronic anhydride pyridine complex, 95%

Codice CAS
95010-17-6
Sinonimi
O'Shea's reagent
Trivinylboroxin pyridine complex

Dimensioni Prezzo ($) Quantità Disponibilità
1g 51,40
5g 158,00
25g 690,00
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Vinylboronic anhydride pyridine complex, 95%

MDL
MFCD03839940

Proprietà chimiche

Formula
C6H9B3O3
Peso formula
161.57
Punto di fusione
44-52°
Sensibilità
Moisture Sensitive
Solubilità
Soluble in methanol.

Applicazioni

Reagent used for Suzuki-Miyaura cross-coupling, stereoselective synthesis via Palladium-catalyzed carboamination, Alkyl-connected 2-amino-6-vinylpurine (AVP) cross linking agent to cytosine base in RNA, Kaiser oxime resin-derived palladacycle as a recoverable polymeric precatalyst in Suzuki-Miyaura cross-coupling reactions in aqueous media and Kinetic resolution of phosphoryl and sulfonyl esters of binaphthol derivatives via Pd-catalyzed alcoholysis of their vinyl ethers.

Note

Moisture Sensitive, store away from water/moisture. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store under dry inert gas.

Letteratura

Kuan-Jen Su; Jean-Luc Mieusset; Vladimir B Arion; Wolfgang Knoll; Lothar Brecker; Udo H Brinker. Efforts toward distorted spiropentanes. Journal of Organic Chemistry. 2010, 75(21), 7494-7497.

Amanda F Ward; and John P Wolfe. Stereoselective synthesis of substituted 1,3-oxazolidines via Pd-catalyzed carboamination reactions of O-vinyl-1,2-amino alcohols.Organic Letters. 2011, 13(17), 4728-4731.

Stable equivalent of the readily-polymerizable vinylboronic acid, first reported by Matteson: J. Org. Chem., 27, 3712 (1962), and more recently adopted by O'Shea as a vinylboron unit for Suzuki cross-coupling reactions with aryl halides to give substituted styrenes: J. Org. Chem., 67, 4968 (2002). The reaction has been applied to the formation of ortho-Boc-amino styrenes, further reaction of which has been developed as a route to diversely functionalized indoles: J. Am. Chem. Soc., 125, 4054 (2003). Copper(II) acetate mediated coupling with phenols affords an efficient synthesis of aryl vinyl ethers: J. Org. Chem., 69, 5087 (2004).

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H315-H319-H335

Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2933.39
TSCA
No

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