Informativa e consenso per l'uso dei cookie

Accetto Il nostro sito salva piccoli pezzi di informazioni (cookie) sul dispositivo, al fine di fornire contenuti migliori e per scopi statistici. È possibile disattivare l'utilizzo di cookies modificando le impostazioni del tuo browser. Continuando la navigazione si acconsente all'utilizzo dei cookie.

90347-66-3 - Methyl 3-iodo-4-methylbenzoate, 98% - 3-Iodo-4-methylbenzoic acid methyl ester - H28734 - Alfa Aesar

H28734 Methyl 3-iodo-4-methylbenzoate, 98%

Codice CAS
90347-66-3
Sinonimi
3-Iodo-4-methylbenzoic acid methyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
5g 52,90
25g 154,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

Methyl 3-iodo-4-methylbenzoate, 98%

MDL
MFCD00230583

Proprietà chimiche

Formula
C9H9IO2
Peso formula
276.07
Indice di rifrazione
1.5975
Sensibilità
Light Sensitive
Solubilità
Not miscible or difficult to mix with water.

Applicazioni

Methyl 3-Iodo-4-methylbenzoate is used as a reagent in the synthesis of [(pyrazolo[1,5-a]pyridmidinyl)ethynyl]benzamides as selective discoidin domain receptor 1 (DDR1) inhibitors. Also used as a reagent in the preparation of orally bioavailable GZD824 targeting Breakpoint Cluster Region-Abelson (Bcr-Abl) kinase and overcoming antitumor drug resistance.

Note

Light Sensitive, store in dark. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Letteratura

Gao, M., et al. Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors. J. Med. Chem. 2013, 56(8), 3281-3295.

Ren, X., et al. Identification of GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) Kinase and Overcomes Clinically Acquired Mutation-Induced Resistance against Imatinib.J. Med. Chem. 2013, 56(3), 879-894.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313-P302+P352a-P362+P364

Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Take off contaminated clothing and wash before reuse.

Altri riferimenti

Codice tariffe armonizzato
2916.39
TSCA
No

Raccomandato

  • A10549

    Methyl 3-iodo-4-methoxybenzoate, 98%
  • A11429

    1,3-Phenylenediacetic acid, 97%
  • B24372

    Methyl 3-bromo-4-methylbenzoate, 99%
  • B25444

    Methyl 3-chloro-5-iodobenzoate, 98%

Visualizzati di recente

Prodotti chimici

Scienze della vita

Metalli e materiali

Catalizzatori

Apparecchiature di analisi e di laboratorio