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90347-66-3 - Methyl 3-iodo-4-methylbenzoate, 98% - 3-Iodo-4-methylbenzoic acid methyl ester - H28734 - Alfa Aesar

H28734 Methyl 3-iodo-4-methylbenzoate, 98%

Codice CAS
90347-66-3
Sinonimi
3-Iodo-4-methylbenzoic acid methyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
5g 55,62
25g 125,60
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Methyl 3-iodo-4-methylbenzoate, 98%

MDL
MFCD00230583

Proprietà chimiche

Formula
C9H9IO2
Peso formula
276.07
Indice di rifrazione
1.5975
Sensibilità
Light Sensitive
Solubilità
Not miscible or difficult to mix with water.

Applicazioni

Methyl 3-Iodo-4-methylbenzoate is used as a reagent in the synthesis of [(pyrazolo[1,5-a]pyridmidinyl)ethynyl]benzamides as selective discoidin domain receptor 1 (DDR1) inhibitors. Also used as a reagent in the preparation of orally bioavailable GZD824 targeting Breakpoint Cluster Region-Abelson (Bcr-Abl) kinase and overcoming antitumor drug resistance.

Note

Light Sensitive, store in dark. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Letteratura

Gao, M., et al. Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors. J. Med. Chem. 2013, 56(8), 3281-3295.

Ren, X., et al. Identification of GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) Kinase and Overcomes Clinically Acquired Mutation-Induced Resistance against Imatinib.J. Med. Chem. 2013, 56(3), 879-894.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P280-P264-P305+P351+P338-P362-P321-P332+P313-P337+P313-P302+P352

Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Take off contaminated clothing and wash before reuse. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists: IF ON SKIN: Wash with plenty of soap and water.

Altri riferimenti

Codice tariffe armonizzato
2916.39
TSCA
No

Raccomandato

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