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H28734 Methyl 3-iodo-4-methylbenzoate, 98%

Codice CAS
90347-66-3
Sinonimi
3-Iodo-4-methylbenzoic acid methyl ester

Stock No. Dimensioni Prezzo ($) Quantità Disponibilità
H28734-06 5g 52,90
H28734-14 25g 154,00
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Methyl 3-iodo-4-methylbenzoate, 98%

MDL
MFCD00230583

Proprietà chimiche

Formula
C9H9IO2
Peso formula
276.07
Indice di rifrazione
1.5975
Storage & Sensitivity
Light Sensitive. Ambient temperatures.
Solubilità
Not miscible or difficult to mix with water.

Applicazioni

Methyl 3-Iodo-4-methylbenzoate is used as a reagent in the synthesis of [(pyrazolo[1,5-a]pyridmidinyl)ethynyl]benzamides as selective discoidin domain receptor 1 (DDR1) inhibitors. Also used as a reagent in the preparation of orally bioavailable GZD824 targeting Breakpoint Cluster Region-Abelson (Bcr-Abl) kinase and overcoming antitumor drug resistance.

Note

Light Sensitive, store in dark. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Letteratura

Gao, M., et al. Discovery and Optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as Novel Selective and Orally Bioavailable Discoidin Domain Receptor 1 (DDR1) Inhibitors. J. Med. Chem. 2013, 56(8), 3281-3295.

Ren, X., et al. Identification of GZD824 as an Orally Bioavailable Inhibitor That Targets Phosphorylated and Nonphosphorylated Breakpoint Cluster Region-Abelson (Bcr-Abl) Kinase and Overcomes Clinically Acquired Mutation-Induced Resistance against Imatinib.J. Med. Chem. 2013, 56(3), 879-894.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313

Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists:

Altri riferimenti

Codice tariffe armonizzato
2916.39
TSCA
No

Raccomandato

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