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39687-95-1 - Methyl isocyanoacetate, 95% - Isocyanoacetic acid methyl ester - H31069 - Alfa Aesar

H31069 Methyl isocyanoacetate, 95%

Codice CAS
39687-95-1
Sinonimi
Isocyanoacetic acid methyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
1g 27,19
5g 77,66
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Methyl isocyanoacetate, 95%

MDL
MFCD00000006
EINECS
254-593-8

Proprietà chimiche

Formula
C4H5NO2
Peso formula
99.09
Punto di ebollizione
75-76°/10mm
Punto di infiammabilità
84°(183°F)
Densità
1.09
Solubilità
Miscible with organic solvents. Slightly miscible with water.

Applicazioni

Methyl isocyanoacetate is used in the copper-catalyzed, diastereoselective synthesis of oxazolines. It is involved in the direct aldol reaction with carbonyl compounds to prepare corresponding oxazoline by using catechol-copper network catalyst. Further, it is also involved in four-component Ugi condensation reaction. It undergoes asymmetric aldol reaction with fluorinated benzaldehyde using gold(I) as a catalyst.

Note

Light and moisture sensitive. Incompatible with strong oxidizing agents, strong bases, strong acids, hydrated iron(II) sulfate, heavy metals and aluminum. Store in a cool place. Keep the container tightly closed.

Letteratura

Abás, S.; Estarellas, C.; Luque, F. J.; Escolano, C. Easy access to (2-imidazolin-4-yl)phosphonates by a microwave assisted multicomponent reaction. Tetrahedron 2015, 71 (19), 2872-2881.

de la Campa, R.; Ortín, I.; Dixon, D. J. Direct Catalytic Enantio- and Diastereoselective Ketone Aldol Reactions of Isocyanoacetates. Angew. Chem. Int. Ed. 2015, 127 (16), 4977-4980.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H331-H302-H312-H314-H318-H227

Toxic if inhaled. Harmful if swallowed. Harmful in contact with skin. Causes severe skin burns and eye damage. Causes serious eye damage. Combustible liquid.

Dichiarazioni precauzionali: P210-P260-P261-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Classe di rischio
8
Gruppo di imballaggio
II
Codice tariffe armonizzato
2926.90
TSCA
No

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