Potassium methoxymethyltrifluoroborate is used in the cross-coupling of mesylated phenol derivatives. The corresponding aryl- and heteroaryl alkoxymethyl compounds are prepared with both electron-rich and electron-poor substituents on the activated alcohol.
OBrien, N. J.; Brzozowski, M.; Wilson, D. J.; Deady, L. W.; Abbott, B. M. Synthesis and biological evaluation of substituted 3-anilino-quinolin-2(1H)-ones as PDK1 inhibitors. Bioorg. Med. Chem. 2014, 22 (14), 3781-3790.
Molander, G. A.; Beaumard, F. Cross-Coupling of Mesylated Phenol Derivatives with Potassium Alkoxymethyltrifluoroborates. Org. Lett. 2011, 13 (15), 3948-3951.
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a