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3-Methyl-5-(trifluoromethyl)benzyl bromide, 97% - H33520 - Alfa Aesar

H33520 3-Methyl-5-(trifluoromethyl)benzyl bromide, 97%

Codice CAS
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 48,80
1g 167,89
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3-Methyl-5-(trifluoromethyl)benzyl bromide, 97%

MDL
MFCD01631610

Proprietà chimiche

Formula
C9H8BrF3
Peso formula
253.06
Sensibilità
Moisture Sensitive

Applicazioni

A series of novel five-membered urea derivatives as potent NK1 receptor antagonists is described. The effects of substitution of a 4-fluoro group at the phenyl ring and the introduction of an α-methyl group at the benzylic position to improve potency was found. 3,5-Bis(trifluoromethyl)benzyl bromide has been used as derivatization reagent in detection of uracil in DNA by GC and negative chemical ionization mass spectrometry.

Note

Moisture Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, moisture, water.

Letteratura

Ho-Jane Shue,; Xiao Chen,; John H. Schwerdt,; Sunil Paliwal,; David J. Blythin,; Lng Lin,; Dalina Cheng Wang,; Gregory A. Reichard,; Hongwu Wang,; John J. Piwinski,; Ruth A. Duffy,; Jean E. Lachowicz,; Vicki L. Coffin,; Amin A. Nomeir,; Cynthia A. Morgan.Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions. Bioorganic & Medicinal Chemistry Letters. 2006, 16(14) ,1065-1069.

Igor Kazmierski,; Mylène Bastienn,; Corinne Gosmini,; Jean-Marc Paris,; Jacques Périchon. Convenient Processes for the Synthesis of Aromatic Ketones from Aryl Bromides and Carboxylic Anhydrides Using a Cobalt Catalysis. J. Org. Chem. 2004, 69(3),936-942.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H314-H318

Causes severe skin burns and eye damage. Causes serious eye damage.

Dichiarazioni precauzionali: P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P363-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Classe di rischio
8
Gruppo di imballaggio
III
Codice tariffe armonizzato
2903.99
TSCA
No

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