4?-Bromo-2,2,2-trifluoroacetophenone may be used in the preparation of carbonyl-bridged bithiazole derivatives. Also used as a reagent to synthesize MK-5046, a selective Bombesin receptor subtype-3 agonist used to treat obesity.
Ie Y, et al. Air-Stable n-Type Organic Field-Effect Transistors Based on Carbonyl-Bridged Bithiazole Derivatives. Adv. Funct. Mater. 201020 (6), 907-13.
Iyassu K. Sebhat; Christopher Franklin; Michael M.-C. Lo; David Chen; James P. Jewell; Randy Miller; Jianmei Pang; Oksana Palyha; Yanqing Kan; Theresa M. Kelly; Xiao-Ming Guan; Donald J. Marsh; Jennifer A. Kosinski; Joseph M. Metzger; Kathryn Lyons; Jasminka Dragovic; Peter R. Guzzo; Alan J. Henderson; Marc L. Reitman; Ravi P. Nargund; Matthew J. Wyvratt; and Linus S. Lin. Discovery of MK-5046, a Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity. ACS Med. Chem. Lett. 20112 (1), 43-47.
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.