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6-trifluoromethyl-2-pyridinecarboxylic acid (4; 87%) was obtained from 2-bromo-6-(trifluoromethyl)pyridine, which was in turn derived from 2-bromo-6-iodopyridine by trifluoromethylating displacement of iodine.
Fabrice Cottet, Marc Marull1, Olivier Lefebvre1 andManfred Schlosser.Recommendable Routes to Trifluoromethyl-Substituted Pyridine- and Quinolinecarboxylic Acids. European Journal of Organic Chemistry. 2003, 8 1559-1568.
Tatsushi Imahori,; Masanobu Uchiyama,; Takao Sakamoto,; Yoshinori Kondo. Regiocontrolled deprotonative-zincation of bromopyridines using aminozincates. Chem. Commun., 2001, (23), 2450-2451.
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.