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102308-32-7 - (S)-(-)-3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, 95% - (S)-(-)-3-tert-Butoxycarbonyl-2,2-dimethyloxazolidine-4-carboxaldehyde - Garner's Aldehyde - H51049 - Alfa Aesar

H51049 (S)-(-)-3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, 95%

Codice CAS
102308-32-7
Sinonimi
(S)-(-)-3-tert-Butoxycarbonyl-2,2-dimethyloxazolidine-4-carboxaldehyde
Garner's Aldehyde

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 59,84
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(S)-(-)-3-Boc-2,2-dimethyloxazolidine-4-carboxaldehyde, 95%

MDL
MFCD00209557

Proprietà chimiche

Formula
C11H19NO4
Peso formula
229.27
Densità
1.06
Indice di rifrazione
1.4450
Sensibilità
Air Sensitive
Solubilità
Slightly soluble in water.

Applicazioni

It is used to prepare γ-aminophosphonates (N-arylamide phosphonates as subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. It is also used to synthesize N-sulfonylated propargylglycine derivatives as metalloproteinase inhibitors. Also widely utilized in the asymmetric synthesis of natural products.

Note

Air Sensitive, store away from air. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from oxidizing agent.

Letteratura

Foss, F., et al. Synthesis and biological evaluation of γ-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorganic & Medicinal Chemistry. 2007, 15(2), 663-677.

Natchus, M., et al. Development of New Carboxylic Acid-Based MMP Inhibitors Derived from Functionalized Propargylglycines. J. Med. Chem. 2001, 44(7), 1060-1071.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,4371
Beilstein
3591324
Codice tariffe armonizzato
2934.99
TSCA
No

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