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143900-43-0 - (R)-1-Boc-3-hydroxypiperidine, 97% - H52556 - Alfa Aesar

H52556 (R)-1-Boc-3-hydroxypiperidine, 97%

Codice CAS
143900-43-0
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 46,50
5g 187,00
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(R)-1-Boc-3-hydroxypiperidine, 97%

MDL
MFCD04115306

Proprietà chimiche

Formula
C10H19NO3
Peso formula
201.27
Punto di fusione
46-50°
Punto di infiammabilità
104°(219°F)

Applicazioni

(R)-1-Boc-3-hydroxypiperidine has been used as a reactant for the synthesis of piperidinyl and pyrrolidinyl butyrates. It has also been used for the synthesis of constrained (-)-S-adenosyl-L-homocysteine (SAH) analogs as DNA methyltransferase inhibitors.

Note

Stable under recommended storage conditions. Incompatible with oxidizing agents and heat.

Letteratura

Christophe Benard; Rahim Mohammad; Neerja Saraswat; Rudong Shan; Samarendra N.Maiti; Peter G.M.Wuts; Michael Stier; Teresa Lints; James Bradow; Jacob B.Schwarz. Convenient preparation of optically pure 3-aryloxy-pyrrolidines. Synthetic Communications: An International Journal for Rapid Communication of Synthetic Organic Chemistry. 2008, 38, (4),517-524

 

Nora Liu; Sascha Hoogendoorn; Bas van de Kar; Allard Kaptein; Tjeerd Barf; Christoph Driessen; Dmitri V.Filippov; Gijsbert A. van der Marel; Mario van der Stelt; Herman S.Overkleeft. Direct and two-step bioorthogonal probes for Bruton's tyrosine kinase based on ibrutinib: a comparative study. Org. Biomol. Chem. 2015, 13, (18),5147-5157

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2933.39
TSCA
No

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