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137076-22-3 - 1-Boc-piperidine-4-carboxaldehyde, 97% - 1-Boc-4-formylpiperidine - H52813 - Alfa Aesar

H52813 1-Boc-piperidine-4-carboxaldehyde, 97%

Codice CAS
137076-22-3
Sinonimi
1-Boc-4-formylpiperidine

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 20,07
1g 68,91
5g 213,60
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1-Boc-piperidine-4-carboxaldehyde, 97%

MDL
MFCD02179019

Proprietà chimiche

Formula
C11H19NO3
Peso formula
213.28
Sensibilità
Air Sensitive
Solubilità
Soluble in methanol.

Applicazioni

1-Boc-piperidine-4-carboxaldehyde is used as reactant for synthesis of Pim-1 inhibitors, selective GPR119 agonists for type II diabetes, M-tropic (R5) HIV-1 replication inhibitors, HDAC inhibitors and selective 5-HT6 antagonists. It is also used as reactant for three-component vinylogous Mannich reactions

Note

Air sensitive. Incompatible with oxidizing agents.

Letteratura

Yibin Xiang; Bradford Hirth; Gary Asmussen; Hans-Peter Biemann; Kimberly A.Bishop; Andrew Good; Maria Fitzgerald; Tatiana Gladysheva; Annuradha Jain; Katherine Jancsics; Jinyu Liu; Markus Metz; Andrew Papoulis; Renato Skerlj; J.David Stepp; Ronnie R.Wei. The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors. Bioorganic & Medicinal Chemistry Letters. 2011, 21, (10),3050-3056

 

Jason W.Szewczyk; John Acton; Alan D.Adams; Gary Chicchi; Stanley Freeman; Andrew D.Howard; Yong Huang; Cai Li; Peter T.Meinke; Ralph Mosely; Elizabeth Murphy; Rachel Samuel; Conrad Santini; Meng Yang; Yong Zhang; Kake Zhao; Harold B.Wood. Design of potent and selective GPR119 agonists for type II diabetes. Bioorganic & Medicinal Chemistry Letters. 2011, 21, (9),2665-2669

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2933.39
TSCA
No

Raccomandato

  • A13697

    Diethyl iodomethylphosphonate, 98+%
  • A14120

    Triethyl phosphonoacetate, 98+%
  • H52571

    1-Boc-piperidine-3-carboxaldehyde, 97%

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