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It is a useful intermediate in pharmaceutical intermediate. Boronic Acids are important chemical building blocks employed in cross coupling reactions. The ability of boronic acids to reversibly bind diol functional groups has been utilized for fluorescent detection of saccharides. The compound Bortezomib utilizes the boronic acid for its proteasome inhibitory effect.
Virgil Percec.; Jin-Young Bae.; Dale H. Hill. Aryl Mesylates in Metal Catalyzed Homocoupling and Cross-Coupling Reactions. 2. Suzuki-Type Nickel-Catalyzed Cross-Coupling of Aryl Arenesulfonates and Aryl Mesylates with Arylboronic Acids.J. Org. Chem. 1995, 60 (4),1060-1065 .
Manfred Baumgarth.; Norbert Beier.; Rolf Gericke. (2-Methyl-5-(methylsulfonyl)benzoyl)guanidine Na+/H+ Antiporter Inhibitors.J. Med. Chem. 1997, 40 (13),2017-2034 .
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.