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146998-31-4 - 4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester, 98+% - DABCYL-N-succinimidyl ester - 4-[(Dimethylamino)azo]benzene-4'-carboxylic acid N-succinimidyl ester - H54402 - Alfa Aesar

H54402 4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester, 98+%

Codice CAS
146998-31-4
Sinonimi
DABCYL-N-succinimidyl ester
4-[(Dimethylamino)azo]benzene-4'-carboxylic acid N-succinimidyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
25mg 37,44
100mg 154,50
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4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester, 98+%

MDL
MFCD00467415

Proprietà chimiche

Formula
C19H18N4O4
Peso formula
366.37
Sensibilità
Moisture Sensitive
Solubilità
Soluble in DMSO.

Applicazioni

4-[4-(Dimethylamino)phenylazo]benzoic acid N-succinimidyl ester is a useful reagent (similar to MANCYL-SE) for labeling proteins or peptides through their amino-groups by forming stable peptide bonds. The succinimidyl ester is reactive with terminal amines or lysines of peptides and other nucleophiles for fluorescent studies of proteins. Its fluorescent properties (has a characteristic broad and intense visible absorption but has no fluorescence) make it an ideal long wavelength quencher and it has been utilized as an acceptor chromophore in FRET studies. It is also used for N-terminal modification of peptides in automated synthesis.

Note

Moisture sensitive. Incompatible with oxidizing agents and heat.

Letteratura

Desmond J O'Shea; Tomas C O'Riordan; Paul J O'Sullivan; Dmitri B.Papkovsky. Homogeneous time-resolved fluorescence assays for the detection of activity and inhibition of phosphatase enzymes employing phosphorescently labeled peptide substrates. Analytica Chimica Acta. 2007, 583,(2), 349-356.

 

Tomas C O'Riordan; James Hynes; Dmitri Yashunski; Gelii V.Ponomarev; Dmitri B.Papkovsky. Homogeneous assays for cellular proteases employing the platinum(II)-coproporphyrin label and time-resolved phosphorescence. Analytical Biochemistry. 2005, 342,(1), 111-119.

Altri riferimenti

Codice tariffe armonizzato
2927.00
TSCA
No

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