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228244-04-0 - (S)-(-)-1-Boc-2-cyanopyrrolidine, 95% - (S)-(-)-1-Boc-pyrrolidine-2-carbonitrile - H57150 - Alfa Aesar

H57150 (S)-(-)-1-Boc-2-cyanopyrrolidine, 95%

Codice CAS
228244-04-0
Sinonimi
(S)-(-)-1-Boc-pyrrolidine-2-carbonitrile

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 63,40
1g 218,00
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(S)-(-)-1-Boc-2-cyanopyrrolidine, 95%

MDL
MFCD01861224

Proprietà chimiche

Formula
C10H16N2O2
Peso formula
196.25
Punto di fusione
33-36°
Punto di infiammabilità
110°(230°F)
Sensibilità
Moisture & Light Sensitive
Solubilità
Slightly soluble in water.

Applicazioni

(S)-(-)-1-Boc-2-pyrrolidinecarbonitrile is used in synthesis of prolyl oligopeptidase inhibitors and is a reagent that is used in the design of potent and selective inhibitors of DPP-4 that exhibits an attractive pharmacokinetic profile as antidiabetics.

Note

Moisture and light sensitive. Store away from light, water/moisture and oxidizing agents. Keep the container tightly closed and place it in a cool, dry and well ventilated condition. Store in dark.

Letteratura

Erik A A Wallén, et al. New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis(l-prolyl-pyrrolidine) amides.J. Med. Chem.,2003,46(21), 4543-4551.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H312-H332-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P301+P312-P312-P363-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2933.99
TSCA
No

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