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Cyclopropylzinc bromide acts as an active nucleophile in palladium-catalyzed cross-coupling of heteroaryl halides.
Coleridge, B. M.; Bello, C. S.; Leitner, A. General and user-friendly protocol for the synthesis of functionalized aryl- and heteroaryl-cyclopropanes by Negishi cross-coupling reactions. Tetrahedron Lett. 2009, 50 (31), 4475-4477.
Shu, C.; Sidhu, K.; Zhang, L.; Wang, X. J.; Krishnamurthy, D.; Senanayake, C. H. Palladium-Catalyzed Cross-Coupling of Cyclopropylmagnesium Bromide with Aryl Bromides Mediated by Zinc Halide Additives. J. Org. Chem. 2010, 75 (19), 6677-6680.
Dichiarazioni di rischio (UE): H225-H261-H302-H333-H314-H318-H351-H335
Highly flammable liquid and vapour. In contact with water releases flammable gas. Harmful if swallowed. May be harmful if inhaled. Causes severe skin burns and eye damage. Causes serious eye damage. Suspected of causing cancer. May cause respiratory irritation.
Dichiarazioni precauzionali: P223-P210-P303+P361+P353-P305+P351+P338-P405-P501a
Keep away from any possible contact with water, because of violent reaction and possible flash fire. Keep away from heat/sparks/open flames/hot surfaces. - No smoking. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.