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4175-77-3 - 2,4-Dibromothiazole, 97% - H60230 - Alfa Aesar

H60230 2,4-Dibromothiazole, 97%

Codice CAS
4175-77-3
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 40,05
5g 157,55
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2,4-Dibromothiazole, 97%

MDL
MFCD01318994

Proprietà chimiche

Formula
C3HBr2NS
Peso formula
242.92
Punto di fusione
80-84°

Applicazioni

2,4-Dibromothiazole is applied as a building block in a synthesis of Melithiazole C employing a highly (E)-selective cross-metathesis between the derived 4-vinylthiazole and a dienote side-chain. It is also used as an intermediate in the preparation of various 2,4-disubstituted thiazole derivatives with biologically active properties such as survival motor neuron (SMN) protein modulators.

Note

Air sensitive. Incompatible with oxidizing agents.

Letteratura

Julian Gebauer; Stellios Arseniyadis; Janine Cossy. A concise total synthesis of melithiazole C. Organic Letters. 2007, 9,(17), 3425-3427.

 

A.Spiess; G.Heckmann; T.Bach. Regio- and stereoselective synthesis of α-chiral 2-substituted 4-bromo-thiazoles from 2,4-dibromothiazole by bromine-magnesium exchange. Building blocks for the synthesis of thiazolyl peptides and dolabellin. Synlett. 2004, (1), 131-133.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H318-H315-H302-H335

Causes serious eye damage. Causes skin irritation. Harmful if swallowed. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P310-P362-P301+P312-P312-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Codice tariffe armonizzato
2934.10
TSCA
No

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