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59557-91-4 - 4-Bromo-2-methoxyaniline, 98% - H61454 - Alfa Aesar

H61454 4-Bromo-2-methoxyaniline, 98%

Codice CAS
59557-91-4
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
1g 24,30
5g 109,00
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4-Bromo-2-methoxyaniline, 98%

MDL
MFCD01204266

Proprietà chimiche

Formula
C7H8BrNO
Peso formula
202.05
Solubilità
Soluble in methanol.

Applicazioni

4-Bromo-2-methoxyaniline is used as a reagent in the synthesis of 3,5-diamino-1,2,4-triazole ureas as potent anaplastic lymphoma kinase (ALK) inhibitors. It is also used as a reagent in the synthesis of chroman-3-amides as potent Rho kinase inhibitors. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff fields.

Note

Keep container tightly sealed. Store in cool, dry conditions in well sealed containers. Incompatible with oxidizing agents.

Letteratura

P. S. Portoghese.; H. Nagase.; A. W. Lipkowski.; D. L. Larson.; A. E. Takemori. Binaltorphimine-related bivalent ligands and their .kappa. opioid receptor antagonist selectivity [Erratum to document cited in CA108(17):150771q]. J. Med. Chem. 1988, 31 (10), 2056-2056.

Kate M. Clapham.; Julia Bardos.; M. Raymond V. Finlay.; Bernard T. Golding.; Edward J. Griffen.; Roger J. Griffin.; Ian R. Hardcastle.; Keith A. Menear.; Attilla Ting.; Paul Turner.; Gail L. Young.; Celine Cano. DNA-dependent protein kinase (DNA-PK) inhibitors: Structure-activity relationships for O-alkoxyphenylchromen-4-one probes of the ATP-binding domain. Bioorganic & Medicinal Chemistry Letters. 2011, 21 (3), 966-970.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H312-H331-H315-H319-H335

Harmful if swallowed. Harmful in contact with skin. Toxic if inhaled. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P405-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2922.29
TSCA
No

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