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2971-79-1 - Methyl piperidine-4-carboxylate, 98% - Piperidine-4-carboxylic acid methyl ester - Methyl isonipecotate - H61754 - Alfa Aesar

H61754 Methyl piperidine-4-carboxylate, 98%

Codice CAS
2971-79-1
Sinonimi
Piperidine-4-carboxylic acid methyl ester
Methyl isonipecotate

Dimensioni Prezzo ($) Quantità Disponibilità
25g 28,96
100g 108,00
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Methyl piperidine-4-carboxylate, 98%

MDL
MFCD00190578

Proprietà chimiche

Formula
C7H13NO2
Peso formula
143.18
Punto di ebollizione
85-90°
Punto di infiammabilità
89°(192°F)
Densità
1.06
Indice di rifrazione
1.4650
Solubilità
Slightly soluble in water.

Applicazioni

Methyl piperidine-4-carboxylate is a reactant for C-2 arylation of piperidines through directed transition metal-catalyzed sp3 C-H activation. It is used as a reactant for synthesis of antitubercular agents, aminopyrazine inhibitors, orally available naphthyridine protein kinase D inhibitors and a scalable catalyst from asymmetric hydrogenation of sterically demanding aryl enamide.

Note

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Letteratura

Hana Prokopcova; Sheba D.Bergman; Karel Aelvoet; Veerle Smout; Wouter Herrebout; Benjamin Van der Veken; Lieven Meerpoel; Bert U.W.Maes. C-2 arylation of piperidines through directed transition-metal-catalyzed sp3 C-H activation. Chemistry: A European Journal. 2010, 16,(44), 13063-13067.

 

Ahmed Kamal; Rajesh V.C.R.N.C. Shetti; Shaik Azeeza; S.Kaleem Ahmed; P.Swapna; A.Malla Reddy; Inshad Ali Khan; Sandeep Sharma; Sheikh Tasduq Abdullah. Anti-tubercular agents. Part 5: Synthesis and biological evaluation of benzothiadiazine 1,1-dioxide based congeners. European Journal of Medicinal Chemistry. 2010, 45,(10), 4545-4553.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335-H227

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. Combustible liquid.

Dichiarazioni precauzionali: P210-P261-P280-P305+P351+P338-P304+P340-P362-P312-P405-P403+P233-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
224128
Codice tariffe armonizzato
2933.39
TSCA
No

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