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60456-23-7 - (S)-(-)-Glycidol, 99+%, ee 99+% - (S)-(-)-Oxirane-2-methanol - (S)-(-)-2,3-Epoxy-1-propanol - H63502 - Alfa Aesar

H63502 (S)-(-)-Glycidol, 99+%, ee 99+%

Codice CAS
60456-23-7
Sinonimi
(S)-(-)-Oxirane-2-methanol
(S)-(-)-2,3-Epoxy-1-propanol

Dimensioni Prezzo ($) Quantità Disponibilità
1g 22,19
5g 85,49
25g 263,01
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(S)-(-)-Glycidol, 99+%, ee 99+%

MDL
MFCD00074874

Proprietà chimiche

Formula
C3H6O2
Peso formula
74.08
Punto di ebollizione
66-67°/19mm
Punto di infiammabilità
66°(151°F)
Densità
1.116
Indice di rifrazione
1.4330
Solubilità
Soluble in chloroform, DMSO and methanol.

Applicazioni

(S)-(-)-Glycidol is employed in the synthesis of chiral (E)-allylic alcohol side-chains for introduction into prostacyclin and prostaglandin frameworks by cross-metathesis. Also used as a starting reagent to synthesize non-peptidic HIV protease inhibitors.

Note

Store in freezer at(-20°C). Keep container tightly closed. Store away from oxidizing agent.

Letteratura

Neil A Sheddan; Johann Mulzer. Cross metathesis as a general strategy for the synthesis of prostacyclin and prostaglandin analogues. Organic Letters. 2006, 8(14), 3101-3104.

Haines TD; Adlaf KJ; Pierceall RM, et al. Direct Determination of MCPD Fatty Acid Esters and Glycidyl Fatty Acid Esters in Vegetable Oils by LC-TOFMS. J. Am. Oil Chem. Soc. 2011, 88(1), 1-14.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H331-H302-H312-H315-H319-H335-H350-H360-H341-H227

Toxic if inhaled. Harmful if swallowed. Harmful in contact with skin. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation. May cause cancer. May damage fertility or the unborn child. Suspected of causing genetic defects. Combustible liquid.

Dichiarazioni precauzionali: P210-P201-P261-P280-P281-P305+P351+P338-P304+P340-P311-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Obtain special instructions before use. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
79783
Classe di rischio
6.1
Gruppo di imballaggio
III
Codice tariffe armonizzato
2910.90
TSCA
No
RTECS
RR0508100

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