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It is applied in an efficient preparation of indolizines through a tandem palladium-catalyzed cross-coupling reaction and cycloisomerization and also in the synthesis, and structure-activity relationships of 2-aminoquinazoline derivatives as a novel class of metabotropic glutamate receptor 5 negative allosteric modulators.
Manfred Schlosser, et al. Silyl-Mediated Halogen/Halogen Displacement in Pyridines and Other Heterocycles.Eur. J. Org. Chem.,2002,244181-4184.
Hyunseok Kim, et al. An efficient preparation of indolizines through a tandem palladium-catalyzed cross-coupling reaction and cycloisomerization.Chem. Commun.,2010,46(34), 6341-6343.
Dichiarazioni di rischio (UE): H302-H315-H319-H335
Harmful if swallowed. Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.