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14774-37-9 - 4-(Hydroxymethyl)tetrahydropyran, 98% - 4-Tetrahydropyranmethanol - H64568 - Alfa Aesar

H64568 4-(Hydroxymethyl)tetrahydropyran, 98%

Codice CAS
14774-37-9
Sinonimi
4-Tetrahydropyranmethanol

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 20,40
1g 52,00
5g 208,00
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4-(Hydroxymethyl)tetrahydropyran, 98%

MDL
MFCD00457804

Proprietà chimiche

Formula
C6H12O2
Peso formula
116.16
Punto di ebollizione
111-115°/15mm
Punto di infiammabilità
61°(142°F)
Indice di rifrazione
1.4600
Solubilità
Slightly soluble in water.

Applicazioni

Used as a reagent in the identification and optimization of pteridinone Toll-like receptor 7 agonists, which can be used for the oral treatment of viral hepatitis. 4-(Hydroxymethyl)tetrahydropyran is also a starting material for [1-[(Tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone which is a drug that acts as CB2 cannabinoid receptor agonist.

Note

Store in cool, dry place in tightly closed container. With adequate ventilation. Store away from oxidizing agent.

Letteratura

Paul A. Roethle; Ryan M. McFadden; Hong Yang; Paul Hrvatin; Hon Hui; Michael Graupe; Brian Gallagher; Jessica Chao; Joseph Hesselgesser; Paul Duatschek; Jim Zheng; Bing Lu; Daniel B. Tumas; Jason Perry; and Randall L. Halcomb. Identification and Optimization of Pteridinone Toll-like Receptor 7 (TLR7) Agonists for the Oral Treatment of Viral Hepatitis. J. Med. Chem.2013 56(18), 7324-7333.

Jennifer M. Frost; Michael J. Dart; Karin R. Tietje; Tiffany R. Garrison; George K. Grayson; Anthony V. Daza; Odile F. El-Kouhen; Betty B. Yao; Gin C. Hsieh; Madhavi Pai; Chang Z. Zhu; Prasant Chandran; and Michael D. Meyer. Indol-3-ylcycloalkyl Ketones: Effects of N1 Substituted Indole Side Chain Variations on CB2 Cannabinoid Receptor Activity. J. Med. Chem.2010 53(1), 295-315.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H318-H315-H335-H227

Causes serious eye damage. Causes skin irritation. May cause respiratory irritation. Combustible liquid.

Dichiarazioni precauzionali: P210-P261-P280-P305+P351+P338-P304+P340-P310-P362-P312-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
103069
Codice tariffe armonizzato
2932.99
TSCA
No

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