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4-Bromopyrazole may be used in the preparation of 4-bromo-1-(2-chloroethyl)-1H-pyrazole. It may be used as starting material in the synthesis of 1,4?-bipyrazoles. Also used in the synthesis of various pharmaceutical and biologically active compounds, including inhibitors. It is also shown to be one of the 4-substituted pyrazoles, being able to act as inhibitor of liver alcohol dehydrogenase.
Guzei IA; and Winter CH. Structural Diversity in the Reaction of Mono- and Disubstituted Pyrazoles with Titanium Tetrachloride. Importance of Hydrogen Bonding and Trends in cis/trans Geometry of Binary Adducts with Unidentate Ligands. Inorg. Chem. 1997 36(20), 4415-4420.
E Alejandre-Durán; M Ruiz-Rubio; R M Claramunt; C López; C Pueyo. Mutagenicity study on pyrazole, seven pyrazole derivatives, and two nitroimidazoles with the L-arabinose resistance test of Salmonella typhimurium. Environmental Mutagenesis.1986 8(4), 611-619.
Dichiarazioni di rischio (UE): H315-H319-H335
Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Dichiarazioni precauzionali: P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves and eye/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.