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1535-65-5 - Difluoromethyl phenyl sulfone, 95% - (Difluoromethylsulfonyl)benzene - H64760 - Alfa Aesar

H64760 Difluoromethyl phenyl sulfone, 95%

Codice CAS
1535-65-5
Sinonimi
(Difluoromethylsulfonyl)benzene

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 21,40
1g 64,30
5g 257,00
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Difluoromethyl phenyl sulfone, 95%

MDL
MFCD01050170

Proprietà chimiche

Formula
C7H6F2O2S
Peso formula
192.18
Punto di fusione
24-25°
Densità
1.324
Indice di rifrazione
1.5000
Solubilità
Soluble in chloroform and water.

Applicazioni

Used as a reagent for the nucleophilic difluoro(phenylsulfonyl)methylation of carbonyls and fluorination. Reagent used for reductive silylation and the preparation of trifluoro- and difluoromethylsilanes by reductive coupling of fluoromethyl sulfones, sulfoxides and sulfides with chlorosilanes, fluoroalkylation/chloroalkylation of α,β-enones, arynes, acetylenic ketones and other Michael acceptors, difluoromethylation of primary alkyl halides via nucleophilic substitution-reductive desulfonylation. Also used as reagent in preparation of α-difluoromethyl amines via stereo selective (phenylsulfonyl)difluoromethylation of chiral sulfinyl aldimines and Anti-difluoropropanediols via potassium tert-butoxide-catalyzed difluoromethylenation of aldehydes.

Note

Keep container tightly closed. With adequate ventilation. Store away from oxidizing agent.

Letteratura

G K Surya Prakash; Jinbo Hu; George A Olah. Preparation of tri- and difluoromethylsilanes via an unusual magnesium metal-mediated reductive tri- and difluoromethylation of chlorosilanes using tri- and difluoromethyl sulfides, sulfoxides, and sulfones. Journal of Organic Chemistry.2003 68(11), 4457-4463.

Chuanfa Ni; Laijun Zhang; Jinbo Hu. Nucleophilic fluoroalkylation of alpha,beta-enones, arynes, and activated alkynes with fluorinated sulfones: probing the hard/soft nature of fluorinated carbanions. Journal of Organic Chemistry.2008 73(15), 5699-5713.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
2259218
Codice tariffe armonizzato
2930.90
TSCA
No

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