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51940-64-8 - Ethyl 2,4-dichloropyrimidine-5-carboxylate, 98% - 2,4-Dichloropyrimidine-5-carboxylic acid ethyl ester - H64788 - Alfa Aesar

H64788 Ethyl 2,4-dichloropyrimidine-5-carboxylate, 98%

Codice CAS
51940-64-8
Sinonimi
2,4-Dichloropyrimidine-5-carboxylic acid ethyl ester

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 57,90
1g 158,62
5g 579,00
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Ethyl 2,4-dichloropyrimidine-5-carboxylate, 98%

MDL
MFCD09910281
EINECS
257-531-8

Proprietà chimiche

Formula
C7H6Cl2N2O2
Peso formula
221.04
Punto di fusione
36-37°
Solubilità
Slightly soluble in water.

Applicazioni

It's employed as an important intermediate for raw material for organic synthesis, agrochemical, pharmaceutical and dyestuff field

Note

Store in cool, dry place in tightly closed container. With adequate ventilation. Store away from oxidizing agent.

Letteratura

Hiroyuki Hisamichi; Ryo Naito; Akira Toyoshima; Noriyuki Kawano; Atsushi Ichikawa; Akiko Orita; Masaya Orita; Noritaka Hamada; Makoto Takeuchi; Mitsuaki Ohta; Shin-ichi Tsukamoto. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorganic & Medicinal Chemistry.2005 16(13), 4936-4951.

Tianfeng Xu; Lianwen Zhang; Shilin Xu; Dr. Chao-Yie Yang; Jinfeng Luo; Fang Ding1, Xiaoyun Lu; Yingxue Liu; Zhengchao Tu; Shiliang Li; Prof. Duanqing Pei; Qian Cai; Prof. Honglin Li; Xiaomei Ren; Prof. Shaomeng Wang; and Prof. Ke Ding. Pyrimido[4,5-d]pyrimidin-4(1H)-one Derivatives as Selective Inhibitors of EGFR Threonine790 to Methionine790 (T790M) Mutants. Angewandte Chemie.2013 125(32), 8545-8548.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
152173
Codice tariffe armonizzato
2933.59
TSCA
No

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