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68957-94-8 - 1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in acetonitrile - 1-Propanephosphonic acid cyclic anhydride - T3P - H66967 - Alfa Aesar

H66967 1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in acetonitrile

Codice CAS
68957-94-8
Sinonimi
1-Propanephosphonic acid cyclic anhydride
T3P

Dimensioni Prezzo ($) Quantità Disponibilità
50g 34,10
250g 137,00
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1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in acetonitrile

MDL
MFCD00006583
EINECS
422-210-5

Proprietà chimiche

Formula
C9H21O6P3
Peso formula
318.19
Solubilità
Miscible with dioxane, terahydrofuran, dimethyl formamide, polar and aprotic organic solvents.

Applicazioni

1-Propylphosphonic acid cyclic anhydride is used as a reagent for amide/peptide bond formation. It is utilized for condensation reactions and alcohol oxidations. It is also used to promote the synthesis of hydroxamic acids from carboxylic acids. Further, it is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.

Note

Moisture sensitive. Incompatible with strong oxidizing agents.

Letteratura

Madhu, C.; Basavaprabhu.; Vishwanatha, T. M.; Sureshbabu, V. V. T3P (propylphosphonic anhydride) mediated conversion of Nα-protected amino/peptide acids into thioacids. 2012, 53 (11), 1406-1409.

Nagendra, G.; Madhu, C.; Vishwanatha, T. M.; Sureshbabu, V. V. An expedient route for the reduction of carboxylic acids to alcohols employing 1-propanephosphonic acid cyclic anhydride as acid activator. Tetrahedron Lett. 2012, 53 (38), 5059-5063.

Prasanna, T. S. R.; Raju, K. M. Quick Access to Bis(indolyl)methanes: T3P as a Novel Catalyst System. J. Korean Chem. Soc. 2012, 56 (1), 1406-1409.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H225-H314-H312-H303-H333

Highly flammable liquid and vapour. Causes severe skin burns and eye damage. Harmful in contact with skin. May be harmful if swallowed. May be harmful if inhaled.

Dichiarazioni precauzionali: P210-P260-P280-P303+P361+P353-P305+P351+P338-P301+P330+P331-P304+P340-P310-P405-P501a

Keep away from heat/sparks/open flames/hot surfaces. - No smoking. Do not breathe dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Immediately call a POISON CENTER or doctor/physician. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Beilstein
5079255
Classe di rischio
3
Gruppo di imballaggio
II
Codice tariffe armonizzato
2934.99
TSCA
No

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