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78111-17-8 - Okadaic acid, 98% - J60155 - Alfa Aesar

J60155 Okadaic acid, 98%

Codice CAS
78111-17-8
Sinonimi

Dimensioni Prezzo ($) Quantità Disponibilità
50microgram 94,10
100microg 167,00
300microg 451,00
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Okadaic acid, 98%

MDL
MFCD00083455

Proprietà chimiche

Formula
C44H68O13
Peso formula
805.02
Modulo
Powder
Solubilità
It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.

Applicazioni

Okadaic acid, is used as an activator of PKC and inhibitor of PP1 and PP2A phosphatases. The hydrophobic backbone of okadaic acid enables it to enter cells where it stimulates intracellular protein phosphorylation. It mimics the effects of insulin, enhances transmitter release at neuromuscular junctions, causes vasodilation and is a very potent tumor promoter. Okadaic acid is an extremely useful tool for studying cellular processes that are regulated by phosphorylation. It is shown to activate atypical protein kinase C in adipocytes.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away fom strong oxidizing agents.

Letteratura

Haystead et al. Effects of the tumour promotor okadaic acid on intracellular protein phosphorylation and metabolism. Nature .  1989, 337,(6202), 78-81.

Nuydens et al. Okadaic acid-induced apoptosis in neuronal cells: evidence for an abortive mitotic attempt. J.Neurochem. 1998, 70,(3), 1124-33.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H300-H310-H330-H315

Fatal if swallowed. Fatal in contact with skin. Fatal if inhaled. Causes skin irritation.

Dichiarazioni precauzionali: P301+P310a-P304+P340-P320-P330-P405-P501a

IF SWALLOWED: IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,6819
Classe di rischio
6.1
Gruppo di imballaggio
I
Codice tariffe armonizzato
2932.19
TSCA
No
RTECS
AA8227800

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