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520-18-3 - Kaempferol, 98+% - 3,4',5,7-Tetrahydroxyflavone - J60373 - Alfa Aesar

J60373 Kaempferol, 98+%

Codice CAS
520-18-3
Sinonimi
3,4',5,7-Tetrahydroxyflavone

Dimensioni Prezzo ($) Quantità Disponibilità
50mg 100,12
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Kaempferol, 98+%

MDL
MFCD00016938
EINECS
208-287-6

Proprietà chimiche

Formula
C15H10O6
Peso formula
286.24
Modulo
Powder
Punto di fusione
276-278°
Solubilità
Soluble in DMSO or ethanol to 100mM

Applicazioni

Kaempferol, is used as an inhibitor of Fatty Acid Synthase, Cox-1 activity, and Topo I. It also Induces caspase-9-mediated apoptosis in a variety of cancer cell lines via downregulation of polo-like kinase 1 (PLK1) expression. Exhibits antioxidant activity and attenuates osteoclastic bone reabsorption in vitro. Also blocks EGF-induced histone H3Ser10 phosphorylation in mouse epidermal JB6 C141 cells.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Keep away fom strong oxidizing agents.

Letteratura

Montero et al. Direct activation of the mitochondrial calcium uniporter by natural plant flavonoids.  Biochem.J. 2004, 384,( Pt 1), 19-24.

Kang et al. () Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells. Eur.J.Pharmacol. 2009, 611 ,( 1-3), 17-21.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319-H335

Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.

Dichiarazioni precauzionali: P261-P280-P305+P351+P338-P304+P340-P362-P312-P321-P405-P403+P233-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Take off contaminated clothing and wash before reuse. Call a POISON CENTER or doctor/physician if you feel unwell. Specific treatment (see label). Store locked up. Store in a well-ventilated place. Keep container tightly closed. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,5274
Beilstein
304401
Codice tariffe armonizzato
2932.99
TSCA
No
RTECS
LK9275200

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