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Ouabain octahydrate, is used as a tool to induce in vivo excitotoxicity. Ouabain, as well as other endogenous digitalis-like compounds, can down-regulate the expression of 14-3-3 proteins in rat lens.
D.I. de Vasconcelos, et al. Anti-inflammatory and antinociceptive activity of ouabain in mice. Mediators Inflamm. 2011, 123,(5), 912-925.
B Hellman, J Sehlin, IB Taljedal. Calcium uptake by pancreatic -cells as measured with the aid of 45 Ca and mannitol- 3 H. American Journal of Physiology . 1971, 221, 1795-1801.
Dichiarazioni di rischio (UE): H300-H330-H373
Fatal if swallowed. Fatal if inhaled. May cause damage to organs through prolonged or repeated exposure.
Dichiarazioni precauzionali: P301+P310a-P304+P340-P320-P330-P405-P501a
IF SWALLOWED: Immediately call a POISON CENTER/doctor IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Specific treatment is urgent (see label). Rinse mouth. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.