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Transferrin (Holo) is the primary iron binding and cell delivery molecule present in serum. Serum-free cell culture systems require a delivery format for iron. It is the preferential delivery form of iron because cells process transferrin bound iron in a physiologically appropriate way through transferrin receptors on the cell surface. It can be used with a wide range of cells types. It is loaded with iron prior to use and can be added directly to iron poor or iron-free cell culture media. It has been used for study in treatment of breast cancer cells with holo-transferrin in combination with dihydroartemisinin results in increased tumor cell death due to elevated levels of intracellular ferrous iron.
Giorgia Salvagiotto; Sarah Burton; Christine A.Daigh; Deepika Rajesh; Igor I.Slukvin; Nicholas J.Seay. A defined, feeder-free, serum-free system to generate in vitro hematopoietic progenitors and differentiated blood cells from hESCs and hiPSCs. PLoS ONE. 2011, 6,(3), e17829.
Francis Biville; Christophe Brezillon; Dario Giorgini; Muhamed-Kheir Taha. Pyrophosphate-mediated iron acquisition from transferrin in Neisseria meningitidis does not require TonB activity. PLoS ONE. 2014, 9,(10), e107612.