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79831-76-8 - Castanospermine, 99% - (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizidine - J61071 - Alfa Aesar

J61071 Castanospermine, 99%

Codice CAS
79831-76-8
Sinonimi
(1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizidine

Dimensioni Prezzo ($) Quantità Disponibilità
100mg 217,33
500mg 856,00
Aggiungi al carrello Aggiungi al preventivo generale Visualizza articolo

Castanospermine, 99%

MDL
MFCD00017555

Proprietà chimiche

Formula
C8H15NO4
Peso formula
189.21
Modulo
Solid
Punto di fusione
213-217°
Solubilità
Soluble in water

Applicazioni

Castanospermine, is used as a glycosidase inhibitor and antiinflammatory agent.castanospermine is used to inhibit syncytium formation between HIV-infected and CD4-expressing cells and may also interfere with infectivity. It has also been demonstrated that this agent inhibits inflammation at the level of leukocyte extravasation in rat models of experimental adjuvant-induced arthritis and autoimmune encephalomyelitis. Castanospermine is an inhibitor of Glucosidase I, Maltase-glucoamylase, and MANBA. Potent inhibitor of α- and β-glucosidases, especially glucosidase l (required for glucoprotein processing by transfer of mannose and glucose from asparagine-linked lipids). Inhibits HIV syncytium formation and replication.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: 2 - 8°C. Keep away from strong oxidizing agents.

Letteratura

Saul et al. Studies on the mechanism of castanospermine inhibition of α- and β-glucosidases. Arch.Biochem.Biophys. 1984, 230,(2), 668-75.

Gruters et al. Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase. Nature. 1987, 330,(6143), 74-7.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H302-H312-H332

Harmful if swallowed. Harmful in contact with skin. Harmful if inhaled.

Dichiarazioni precauzionali: P261-P280-P264-P270-P304+P340-P301+P312-P312-P363-P322-P501a

Avoid breathing dust/fume/gas/mist/vapours/spray. Wear protective gloves/protective clothing/eye protection/face protection. Wash thoroughly after handling. Do not eat, drink or smoke when using this product. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. Wash contaminated clothing before reuse. Specific measures (see label). Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,1896
Beilstein
3588654
Codice tariffe armonizzato
2933.99
TSCA
No

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