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58970-76-6 - Bestatin - Ubenimex - N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutanoyl]-L-leucine - J61106 - Alfa Aesar

J61106 Bestatin

Codice CAS
58970-76-6
Sinonimi
Ubenimex
N-[(2S,3R)-3-Amino-2-hydroxy-1-oxo-4-phenylbutanoyl]-L-leucine

Dimensioni Prezzo ($) Quantità Disponibilità
100mg 86,70
250mg 167,00
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Bestatin

MDL
MFCD00083262
EINECS
261-529-2

Proprietà chimiche

Formula
C16H24N2O4
Peso formula
308.37
Modulo
Powder
Punto di fusione
233-236°
Solubilità
Soluble in water (<1 25), DMSO (2 mg/ml), methanol (5 mg/ml), 1eq. NaOH (50 mM), ethanol (<1 mg/ml at 25°C), acetic acid, aq. HCl, and alkaline solution. Insoluble in ethyl acetate, benzene, hexane, and chloroform.

Applicazioni

Bestatin can indirectly act on monocytes by inhibiting Aminopeptidase B, which in turn inhibits the catabolism of tuftsin. Bestatin has also been shown to inhibit Leukotriene A4 hydrolase. It can directly stimulate lymphocytes through its fixation on the cell surface. The agent has been used in multiple leukemia studies. Bestatin is an aminopeptidase inhibitor, inhibits enkephalin metabolism and leukotriene A4 hydrolase. Inhibits tumor cell proliferation.

Note

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.

Letteratura

Umezawa et al. Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J.Antibiot. 1976, 29,(1), 97-9.

Imamura and Kimura. Effect of ubenimex (Bestatin) on the cell growth and phenotype of HL-60 and HL-60R cell lines: up- and down-regulation of CD13/aminopeptidase N. Leuk.Lymphoma . 2000, 37,(5-6), 663-7.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni precauzionali: P260-P201-P280-P304+P340-P405-P501a

Do not breathe dust/fume/gas/mist/vapours/spray. Obtain special instructions before use. Wear protective gloves/protective clothing/eye protection/face protection. IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing. Store locked up. Dispose of contents/container in accordance with local/regional/national/international regulations.

Altri riferimenti

Merck
14,9842
Codice tariffe armonizzato
2924.29
TSCA
No
RTECS
OH2915000

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