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14611-52-0 - (R)-(-)-Deprenyl hydrochloride - Selegiline - J61286 - Alfa Aesar

J61286 (R)-(-)-Deprenyl hydrochloride

Codice CAS
14611-52-0
Sinonimi
Selegiline

Dimensioni Prezzo ($) Quantità Disponibilità
250mg 66,40
1g 198,00
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(R)-(-)-Deprenyl hydrochloride

MDL
MFCD00069299

Proprietà chimiche

Formula
C13H17N•HCl
Peso formula
223.74
Modulo
Crystalline Powder
Solubilità
Soluble in water at 100mM

Applicazioni

(R)-(-)-Deprenyl hydrochloride provides neuroprotection which may be relevant to Parkinson’s disease, Alzheimer’s disease, Huntington’s disease, and stroke. It is an inhibitor of MAO-B (monoamine oxidase-B) which demonstrates extensive neuroprotective effects shown to be uncorrelated with MAO-B inhibiting activity. It demonstrates protection of dopaminergic neurons from excitotoxicity mediated by NMDA activation. It also demonstrates decreases in apoptosis of PC12 neuronal cells accompanied with an induction of new protein synthesis through direct transcriptional and translational interaction, and reduced cell death and internucleosomal DNA degredation at concentrations too low to inhibit MAO-B.

Note

Stable under recommended storage conditions. Incompatible with oxidizing agents.

Letteratura

J.W.Tetrud; J.W.Langston. The effect of deprenyl (selegiline) on the natural history of Parkinson's disease. Science. 1989, 245,(4917), 519-522.

 

E.W.Tsang; C.Hamani; E.Moro; F.Mazzella; U.Saha; A.M.Lozano; M.Hodaie; R.Chuang; T.Steeves; S.Y.Lim; B.Neagu; R.Chen. Subthalamic deep brain stimulation at individualized frequencies for Parkinson disease. Neurology. 2012, 78,(24), 1930-1938.

Rischio GHS e dichiarazioni precauzionali

Dichiarazioni di rischio (UE): H315-H319

Causes skin irritation. Causes serious eye irritation.

Dichiarazioni precauzionali: P280a-P264-P305+P351+P338-P321-P332+P313-P337+P313

Wear protective gloves and eye/face protection. Wash thoroughly after handling. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. Specific treatment (see label). If skin irritation occurs: Get medical advice/attention. If eye irritation persists:

Altri riferimenti

Merck
14,8428
Codice tariffe armonizzato
2921.49
TSCA
No
RTECS
DA0292500

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